How is bacterial killing mediated by the complement system?
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How is bacterial killing mediated by the complement system?
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The complement system refers to a series of 20 proteinscirculating in the blood and tissue fluids Most of the proteinsare normally inactive but in response to the recognition ofmolecular components of microorganisms they become sequentiallyactivated in an enzyme cascade the activation of one proteinenzymatically cleaves and activates the next protein in thecascade Complement can be activated via three different pathwayswhich can each cause the activation of C3cleaving it into a large fragment C3b that actsas an opsonin and a small fragmentC3a
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