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How does the Near Attack Conformation (NAC) contribute to enzyme function? How can an enzyme put...

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Biology

How does the Near Attack Conformation (NAC) contribute to enzymefunction? How can an enzyme put a substrate into an energeticallyunfavorable conformation? How does modern drug design utilize NAC?Please go into detail, provide examples, and use diagrams to helpillustrate your explanation. Especially use diagramsplease.  

NAC means \"Near Attack Conformation\". I am struggling tounderstand how all of these relate. Thank you so much for thehelp!

Answer & Explanation Solved by verified expert
4.3 Ratings (899 Votes)
substrate may adopt nearattackconformations NAC which moreapproximate the bound transition state and it is the binding ofthe NAC    See Answer
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