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How does metabolic ratio determine the activity of CYTOCHROME P450?

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Medical Sciences

How does metabolic ratio determine the activity of CYTOCHROMEP450?

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Xenobiotics including therapeutic agents typically undergo chemical modification in the body to aid their elimination The cytochrome P450 P450 monooxygenase enzymes are the predominant enzyme system involved in human drug metabolism accounting for about 75 of the total reactions for drug metabolism in the human liver intestine and kidney The rate at which drugs and xenobiotics are metabolized by P450s affects the pharmacokinetics of the compound and consequently may also affect the pharmacodynamic response Drug interactions involving either induction or inhibition of P450 enzymes can alter rates of P450mediated metabolism However significant interindividual variation in basal rates of P450mediated drug metabolism have been observed including up to 30 to 40fold variation for CYP3A enzymes 100fold variation for CYP2D6 50 to 60fold variation for CYP2B6    See Answer
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