How does GPCR work with opioid receptors and the antagonist Narcan?

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How does GPCR work with opioid receptors and the antagonistNarcan?

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All Opioid receptor types located in Peripheral Nervous System GI system cerebral cortex striatum hippocampus dorsal horn Types of opiods receptor mu receptors midbrain periaqueductal gray kappa receptors midbrain periaqueductal gray delta    See Answer
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