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How could you show that the adaptor protein AP2 has a phosphatidylinositol-4,5-bisphosphate (PIP2) binding domain? In like...

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Biology

How could you show that the adaptor protein AP2 has aphosphatidylinositol-4,5-bisphosphate (PIP2) binding domain?

In like a simple-ish explanation please.

Answer & Explanation Solved by verified expert
4.4 Ratings (1133 Votes)
The clathrin adaptor complex AP2 serves to coordinate clathrincoated pit assembly with the sorting of transmembrane cargo proteins at the plasmalemma How precisely AP2 assembly and cargo protein recognition at sites of endocytosis are regulated has remained unclear but recent evidence implicates phosphoinositides in particular phosphatidylinositol 45bisphosphate PI45P2 in these    See Answer
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