Logo
Home Study Material Contact Search
AI Chat FREE
  1. sciences
  2. biology
  3. hbs, the variant of hemoglobin responsible for sic

HbS, the variant of hemoglobin responsible for sickle-cell anemia, aggregates into long chains in aqueous, biological conditions...

80.2K

Verified Solution

Question

Biology

HbS, the variant of hemoglobin responsible for sickle-cellanemia, aggregates into long chains in aqueous, biologicalconditions (pH 7.4, 37oC, some salt and bufferpresent).

  1. Explain this phenomenon from a molecular point of view. Why doesit form chains, not globular aggregates?

  2. Why is this phenomenon unsurprising to biochemists familiar withthe details of protein folding?

Answer & Explanation Solved by verified expert
3.5 Ratings (621 Votes)
Normal hemoglobin Hb is made up of 2 alpha subunits and 2 beta subunits In sickle hemoglobin HbS a missense mutation results in substitution of glutamicacid acid a hydrophilic amino acid with valine a hydrophobic amino acid on the surface of HbS in the sixth    See Answer
Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:
  • Unlimited Question Access with detailed Answers
  • Zin AI - 3 Million Words
  • 10 Dall-E 3 Images
  • 20 Plot Generations
  • Conversation with Dialogue Memory
  • No Ads, Ever!
  • Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!
Become a Member

Other questions asked by students

Finance
1.2K views

The following information applies to the next 6 questions. Suppose that the stripped U.S. Treasury bonds were...

Medical Sciences
1.2K views

Insertion of aquaporins in tubular epithelial cells results from the actions of _____on the_____: Group of answer...

Basic Math
1.2K views

At Burnt Mesa Pueblo, archaeological studies have used the method of tree-ring dating in an effort...

Physics
1.2K views

3 4 x 100 joule A fully charged capacitor has a capacitance C It is...

Basic Math
1.2K views

Using DeMoivre s theorem find 4 2j 5 KIL This question 3 point s 4...

Basic Math
1.2K views

At a school there are 10 students taking onlyChemistry, 9 students taking only Physics,5 students...

Accounting
1.2K views

A company retired $75 million of its 9% bonds at 102 ($76.5 million) before their...

Accounting
1.2K views

For the year 2021, Jones Company budgeted $220,000 for direct labor and $460,000 for factory...

Accounting
1.2K views

This corporation repairs small appliances and sells parts and replacements. They have elected to use...

Accounting
1.2K views

compute the predetermined overhead rate Required: 1. Compute the predetermined overhead...

Finance
1.2K views

answer asap and i will upvote Smith Co. has the following target...

Finance
1.2K views

Consider the following information: Rate of Return If State Occurs Stock A Stock B State...