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  3. h n ch 01 phenylalanine ch phenylpyruvate 02 tissu

H N CH 01 phenylalanine CH phenylpyruvate 02 tissue protein phenylalanine hydroxylase H 0 BHA...

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H N CH 01 phenylalanine CH phenylpyruvate 02 tissue protein phenylalanine hydroxylase H 0 BHA NADH H dietary protein NAD melanin epinephrine H N CH Phenylketonuria tyrosine CH OH thyroxine p hydroxyphenylpyruvate homogentisate maleylacetoacetate fumarylacetoacetate fumarate acetoacetate 10 The cause for the mental retardation associated with untreated PKU is not completely understood but it is believed to arise from the high concentration of phenylpyruvate which is a product of a transamination reaction with phenylalanine and a ketoglutarate The phenylpyruvate is believed to be toxic to the developing brain Write the balanced equation for the transamination of phenylalanine to phenylpyruvate and include the structures of the reactants and products Identify any cofactors needed

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