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Germline mutations occur in sperm or egg and are heritable, whereas somatic mutations occur in non-germ...

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Biology

Germline mutations occur in sperm or egg and are heritable,whereas somatic mutations occur in non-germ cells and are notheritable. Imagine that you are working in a laboratory which isstudying on tissue/cell specific mutation pattern. You have all thetools (such as cell culture, imaging, sequencing etc.) andmaterials (such as genomic DNA, tissue and primary fibroblast cellsfrom a human individuals). By using a NGS analysis please set upexperiments/pipeline, including which method/algorithm would youuse to map your data and call the somatic and germline mutations.You should focus on the question “How can you distinguish betweengermline and somatic mutations ?” (Please indicate thesteps/methods/algorithms only, No need to indicate thedetails).

Answer & Explanation Solved by verified expert
3.9 Ratings (495 Votes)
Answer Germline mutations are analyzed byperforming singlenucleotide variants SNVs in DNA from progenynot present in parental DNA though somatic mutations arerecognized as those present in solitary amplified fibroblasts orunamplified fibroblast replicas but not    See Answer
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