Genetic deficiency in RAG-1 and genetic deficiency in TAP1 both lead to the same outcome: severe...

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Biology

Genetic deficiency in RAG-1 and genetic deficiency in TAP1 bothlead to the same outcome: severe combined immunodeficiency (SCID),in which a patient has an almost completely nonfunctional adaptiveimmune response and is unable to fight off infections with normallyharmless microbial organisms. â€‹EXPLAIN WHYâ€‹ deficiency in these twovery different genes has the same clinical outcome. How will RAG-1deficiency affect the immune system? How will TAP1 deficiencyaffect the immune system? How are these outcomes similar, and howare they different? Why would they give rise to the same set ofmedical symptoms?

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RAG1 or RAG2 deficiency causes a form of autosomal recessive TBNK SCID It accounts for approximately 4 of all SCID cases The enormous diversity of specific immunoglobulinsB cell receptors and T cell receptors is generated through a process of VDJ recombination RAG deficiency is considered an autosomal recessive disease The disorder is generally identified in infants Complete lossoffunction in RAG12 the main components responsible for VDJ recombination activity produces severe immunodeficiency in humans Hypomorphic RAG variants can retain partial recombination See Answer

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