Furosemide: Relative to normal, what would happen if the drug furosemide inhibits Na+/K+ and Na+/Cl- symport channels in the...

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Medical Sciences

Furosemide: Relative to normal, what would happen if thedrug furosemide inhibitsNa^+/K⁺ andNa^+/Cl^-symport channels in the thick segment of the ascending limbof the nephron tubule? Explain your reasoning foreach.
What would happen to water loss from the descendinglimb? Why.
What would happen to the osmolarity of the filtrateinside the bottom of the nephron loop? Why?
What would happen to the loss of salt (NaCl) from thethin segment of the ascending limb. Why?

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4.1 Ratings (477 Votes)

Normalphysiology and mechanism of FurosemideLoop diuretics eg furosemide act on the loop of Henle toreabsorb Na and water to the blood In thick ascending limb NaK and Cl ions are actively transported from the filtrate into thecell by the membrane cotransporter protein NaK2Cl pump andthen to the interstitial fluid by NaK symporter and NaClsymporter Hence in the descending limb the water moleculesdiffuses out from the low solute concentration region to the highersolute concentration region of interstitial fluid This makes thefiltrate more concentrated as it moves down the descending limb Itbecomes less See Answer

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