Fisher Esterification of m-Nitrobenzoic Acid to produce methyl m-nitrobenzoate Lab Report Purpose Statement: DiscussionÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â (15 points) a. Carbonyl compounds can...

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Chemistry

Fisher Esterification of m-Nitrobenzoic Acid to produce methylm-nitrobenzoate Lab Report
Purpose Statement:
DiscussionÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â (15 points)
a. Carbonyl compounds can be divided in two groups. One groupwill consist of acyl halides, anhydrides, carboxylic acids, esters,amides; the second group consists of aldehydes and ketones. Eventhough all the compounds are carbonyl compounds, they react bydifferent mechanisms. Differentiate the mechanism of reaction ofthe two carbonyl groups;
b. What is the order of reactivity of carbonyl compounds (mostreactive to least reactive)? Include both carbonyl groups in thesequence and provide an explanation for the order of reactivity
c. Fisher Esterification is a nucleophilic acyl substitution. Inthis reaction, identify the electrophile and the nucleophilecompounds.
The electrophile in this reaction is the carbocation formed,whereas the nucleophile is the
d. Elaborate on the reactivity of carboxylic acids. Explain theneed for the acid.
e. How IR changes allow you to predict the success of this reaction(Fisher Esterification)?
f. How 1H NMR can help you to predict the success of this reaction(Fisher Esterification)?

Answer & Explanation Solved by verified expert

4.3 Ratings (736 Votes)

a The first group of carbonyl compound contains a leaving group eg In acyl halide the halide is leaving group in anhydrides the OCOCH3 is leaving group like that But in second goup of compounds ie aldehydes ketons does not contains any leaving groupThe first group react with nucleophile with loss of leaving group while in second group the nucleophile reacts with different mechanism b Order of reactivity of carbonyl compounds Acyl halide acid See Answer

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