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Figure 5 Figure 1 from Broadhursta et al 2016 reproduced with permission from American Society...

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Biology

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Figure 5 Figure 1 from Broadhursta et al 2016 reproduced with permission from American Society for Microbiology Analyte method Outcome Acute illness Y Non fatal IgG ELISA Fatal Y IgM ELISA Antigen ELISA 2000 RNA RT PCR Non fatal Fatal Non fatal Fatal Non fatal Fatal Incubation period 2 21 days ND 3 5 Symptom onset Seen in a majority of cases Seen in a minority of cases ND Not detected 9 12 15 Convalescence 18 21 24 27 39 33 36 39 42 45 Days post symptom onset IgG antibodies are detectable for years following infection loss of IgG antibodies has not been characterized 80 Years IgM antibodies are undetectable by day 80 of illness in nearly all patients however IgM antibody detection has been reported at day 168 17 Viral antigen and RNA levels increase until the time of death in fatal cases

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