Familial hypercholesterolemia is a genetic disease that affectsapproximately one in 500 people worldwide. There is more than onegenetic cause of the disease. In one type, heterozygous individualshave cholesterol levels >250 as children and often >300 asadults. However, homozygotes have cholesterol levels of >600 aschildren and can die of heart attacks in their 20s. Theseindividuals entirely lack a functional LDL receptor. Which of thefollowing would be the best description of the inheritance of thisform of hypercholesterolemia? A. dominant epistatis B. codominantC. incompletely dominant D. complementary E. recessiveepistatis
Iris and Raj just found out that they are going to have a baby.Iris’s maternal grandmother had Alper’s syndrome, which isinherited in an autosomal recessive manner. Iris’s parents arenormal and you can assume her father is not a carrier. There is nohistory of this disorder in Raj’s family, so assume no one in hisfamily is a carrier. What is the probability this baby will be acarrier for Alper’s syndrome? A. 0 B. 1/4 C. 1/2 D. 3/4 E. 2/3
Assume that a cross is made between AaBb and aabb plants and theoffspring of the cross demonstrate the phenotypes associated withAB and ab in equal proportion. The results are consistent withwhich circumstances?
