Explain the role of allostery in glycogene phosphorylase in the
activation of PP1 in liver cells.
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Chemistry
Explain the role of allostery in glycogene phosphorylase in theactivation of PP1 in liver cells.
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Glycogen phosphorylase is regulated by both allosteric control and by phosphorylation Hormones such as epinephrine insulin and glucagon regulate glycogen phosphorylase using second messenger amplification systems that are linked to G proteins Glucagon activates adenylate cyclase through a seven transmembrane receptor coupled to Gswhich in turn activates adenylate cyclase to increase intracellular concentrations of cAMP cAMP binds to and releases an active form of protein kinase A PKA Next PKA phosphorylates phosphorylase kinase which in turn phosphorylates glycogen phosphorylase b
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