Explain and describe the key differencesbetween these two sets of experiments:

Sets of Experiments I: HCV StatusExperiments

In the first set of experiments, examine the blood samples ofindividuals with known HCV status. There are three groups ofindividuals in this experimental set: (1) individuals with chronichepatitis C (this includes patients known to have chronic hepatitisC or blood donors who are known to have passed HCV ontorecipients); (2) individuals with acute hepatitis C infections orblood donors who may have passed HCV onto recipients; (3) a controlgroup of individuals, including normal blood donors (long timeblood donors with no history of passing HCV onto recipients) orpatients with hepatitis caused by alcohol or primary biliarycirrhosis. Repeat the assay four times per sample to assureconsistency.

Sets of Experiments II: Blood Transfusion RecipientsExperiments

In the second set of experiments, examine the blood oftransfusion recipients known to have received blood from HCVpositive donors. Assay the positive donors to determine the levelsof HCV antibodies in their blood. Assay the recipients' blood everythree months for twelve months in order to determine if HCVantibody levels increase or remain stable. As a control, assayrecipients of blood transfusion from blood donors who were negativeaccording to the HCV antibody assay. Assay the recipients of thesenegative donors every three months for twelve months.