Excessive alcohol consumption has been strongly linked with fatty liver disease (steatosis) and individuals with defective very...

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Biology

Excessive alcohol consumption has been strongly linked withfatty liver disease
(steatosis) and individuals with defective very low densitylipoprotein cholesterol
(VLDL-c) are at higher risk of developing the condition. Explainhow excessive
alcohol intake can be a risk factor of steatosis and the increaserisk in alcohol
consumers with defective VLDL-c.
b. Triglycerides (TG) mobilization from adipocytes is crucialfor survival during
starvation. A patient was found losing weight and showed drasticreduction of
energy (ATP) within few days of fasting. Further laboratoryinvestigations
revealed that the patient lacks the ability to store fats, markedby high rate of TG
mobilization. Give the possible reasons for the increased lipolysisand also
explain how albumin level can be used as an indicator oflipolysis.

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Excessive alcohol consumption is a serious global healthcare problem The liver sustains the greatest degree of injury of tissue by heavy drinking as it is the primary site of ethanol metabolism Chronic and excessive consumption of alcohol can produce a wide spectrum of hepatic lesions The most characteristic of that are steatosis hepatitis and fibrosis etc Steatosis is the earliest response to heavy drinking It is characterized by the deposition of fat in hepatocytes Steatosis can progress to steatohepatitis It is a more severe inflammatory kind of liver injury This stage of liver disease can lead to the development of fibrosis During this there is excessive deposition of extracellular matrix proteins The fibrotic responses begin with active pericellular fibrosis It may progress to cirrhosis which is characterized by excessive liver scarring vascular alterations and eventual liver failure Among problem drinkers about 35 people develop advanced liver disease as a number of disease modifiers exacerbate slow or prevent alcoholic liver disease progression There are still no FDAapproved pharmacological or nutritional therapies for treating patients with alcoholic liver disease Cessation of drinking is an integral part of therapy Liver transplantation remains See Answer

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