Enzymes When k2 is very small compared to k1 the KM becomes aKd (or i...

Enzymes. When k2 is very small compared to kâ€“1 the KM becomes a Kd (or in...

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Chemistry

Enzymes. When k2 is very small compared to kâ€“1 the KM becomes aKd (or in some textbooks this is called a KS ) for the ES complex.A Kd is really an equilibrium constant (Keq ) for a dissociationreaction in which the products are the dissociated form of thereactants. Write the reaction for which this Kd equals the Keq foryour reaction. Make a generalization about the relationship betweenKM and enzyme-substrate binding affinity.
When k2 is very small compared to k1 and kâ€“1, what process israte determining?

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A small Km indicates that the enzyme requires only a small amount of substrate to become saturated Hence the maximum velocity is reached at relatively low substrate concentrations A large Km indicates the need for high substrate concentrations to achieve maximum See Answer

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