During the fall of 2012, a multi-state outbreak of meningitisoccurred. The source of the infection was traced to contaminatedmethylprednisolone acetate, a steroid commonly used to treat backpain. Each of the infected people had received an injection of thesteroid contaminated with the fungus Exserohilum rostratum. Whilethe investigation is still pending, one current area of focus isthe quality-assurance practices of the company responsible formanufacture of the drug. Quality assurance (QA) refers to theexamination of the process of manufacturing a drug. QA practicesare governed by both federal and local agencies, and they help toensure that manufacturing practices for products such as drugsguarantee both efficacy and safety of the product. Quality control(QC) is an aspect of QA that focuses on the end-product of theprocess. During the production of a drug, one facet of a QCtechnician’s job is to evaluate microbiological safety during theproduction process. As you answer the following questions, imaginethat you are working as a QC technician at a pharmaceuticalcompany.

Part A

During production of a drug, all work area surfaces must bedisinfected using sterilized disinfectants. Which of the followingstatements about disinfectants are true?

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Disinfectants destroy all microbes present on a surface.

Disinfectants are used to inhibit or destroy pathogens.

Disinfection can be used to treat work surfaces as well asworkers (i.e., washing hands).

Disinfection can occur by physical or chemical means.

Endospores and viruses can resist disinfectant treatment.

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Part B

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Part C

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Part D

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Part E

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