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Do every MHC class II molecule on a single dendritic cell present the same peptide fragment?

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Biology

Do every MHC class II molecule on a single dendritic cellpresent the same peptide fragment?

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3.8 Ratings (369 Votes)
The answer is no MHC Class 2 molecules on a particular DC can present different peptides to CD4 T cells MHC I and MHC II molecules are unique in the proteome because of their extreme polymorphism 10000 different alleles of MHC I molecules have been identified thus far This has interesting consequences Polymorphic residues on the top alpha helixes interact with the TCR and are the basis for the specificity of TCRs for both an antigen peptide plus a particular allelic form of an MHC molecule a phenomenon    See Answer
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