Diverse chemokine receptors are thought to be involved during HIV infection into T cells and macrophages....

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Biology

Diverse chemokine receptors are thought to be involved during HIVinfection into T cells and macrophages. (1) How chemokines areacting to regulate the viral infection in these cells? (2) Wouldblocking the chemokine down-stream signaling pathways in the HIVtarget cells attenuate the progression to AIDS? (3) Why or whynot

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Solution 1 HIV infection leads to the proliferation of viral particles death of the infected cells and destruction of host immune system HIV carries a glycoprotein complex of gp160 which consists of gp120 surface glycoprotein and gp41 transmembrane glycoprotein on their outer envelope The gp120 protein is responsible for binding to the CD4 T cells The CD4 competent gp120 proteins interacts and binds to the CD4 receptors hosted on the outer surface of the Tcells This binding leads to further folding See Answer

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