Discuss how the Human and Neanderthal OR1K1 proteins are similar and different including the implications on...

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Biology

Discuss how the Human and Neanderthal OR1K1 proteins are similarand different including the implications on how this specificolfactory receptor may have functioned differently in Neanderthalscompared to humans. Be sure to include the names of the amino acidsthat have changed and what impact you believe this change will haveon the overall protein structure and function

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Mutations related to 78 amino acid changes that are specific to presentday humans their ancestral allelic states being present in both Neanderthal and chimpanzees These changes occurred in 73 different genes with diverse functional activities For instance four of them OR2AT4 OR4D9 OR52W1 and OR1K1 encode olfactory receptors and are located in chromosomes 11 and 9 respectively One of the similarity is 26 33 of them are also present in the Denisova hominin including those of the above mentioned chromosome 11 olfactory genes Initially three explanations for this sharing of derived alleles among modern humans and Denisovans were advanced First contamination with modern human DNA Nonetheless it is unlikely that contamination could explain this degree of sharing since the level of contamination was calculated to be less than 1 Second C T and G A See Answer

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