Describe the V(D)J and VJ arrangements that occur to generate the variable region of the heavy...

90.2K

Verified Solution

Question

Biology

Describe the V(D)J and VJ arrangements that occur to generate thevariable region of the heavy and light chains of an antibody. Besure to list the arrangements in the order in which they occur foreach chain. Be sure to include discussion of the following:RAG-1/RAG-2, RSS, Ku, Artemis, DNA Dependent protein kinase, DNAligase/XRCC4, and terminal deoxynucleotidyl transferase (TdT) andthe signal joint.
Please help, i donâ€™t understand that at all:(

Answer & Explanation Solved by verified expert

4.1 Ratings (529 Votes)

VDJ rearrangement means a rearrangement of variable V joining J and in some cases diversity D gene segments in random fashion This rearrangement occurs in primary lymphoid organs ie bone marrow for B cells and thymus for T cells and results in and results in the highly diverse range of antibodies that are found on B cells and T cell receptors TCRs that are present on T cells VDJ recombination process is carried by group of enzymes collectively termed as VDJ recombinase See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member