Describe the selection process of alpha/beta T cells and use the following words in your description:...

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Biology

Describe the selection process of alpha/beta T cells and use thefollowing words in your description: lymphotactin, prothymocyte,double negative thymocyte, double positive thymocyte, singlepositive thymocyte, cortex, medulla, Hassall's corpuscles, postcapillary venule

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Answer The recognition of selfpeptides that are embedded in major histocompatibility complex MHC molecules on thymic antigenpresenting cells APCs is critical for determining the fate of developing T cells Somewhat paradoxically recognition of self can elicit diametrically opposed outcomes On one hand it is essential for thymocyte survival and commitment to either the CD4 or CD8 T cell lineage that is for positive selection of thymocytes On the other hand recognition of self can be a death verdict for thymocytes mediating the negative selection of See Answer

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