Describe the components of the clotting cascade which are NOT directly involved in the sequence. What...

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Medical Sciences

Describe the components of the clotting cascade which are NOTdirectly involved in the sequence. What do they do?

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Number andor name Function I fibrinogen Forms clot fibrin II prothrombin Its active form IIa activates I V VII VIII XI XIII protein C platelets III tissue factor or tissue thromboplastin Cofactor of VIIa formerly known as factor III IV calcium Required for coagulation factors to bind to phospholipid formerly known as factor IV V proaccelerin labile factor Cofactor of X with which it forms the prothrombinase complex VI Unassigned old name of Factor Va VII stable factor proconvertin Activates IX X VIII Antihemophilic factor A Cofactor of IX with which it forms the tenase complex IX Antihemophilic factor B or Christmas factor Activates X forms tenase complex with factor VIII X StuartPrower factor Activates II forms prothrombinase complex with factor V XI plasma thromboplastin antecedent Activates IX XII Hageman factor Activates factor XI VII prekallikrein and plasminogen XIII fibrinstabilizing factor Crosslinks fibrin von Willebrand factor Binds to VIII mediates platelet adhesion prekallikrein Fletcher factor Activates XII and prekallikrein cleaves HMWK highmolecularweight kininogen HMWK Fitzgerald factor Supports reciprocal activation of XII XI and prekallikrein fibronectin Mediates cell adhesion antithrombin III Inhibits IIa Xa and other proteases heparin cofactor II Inhibits IIa cofactor for heparin and dermatan sulfate minor antithrombin protein C Inactivates Va and VIIIa protein S Cofactor for activated protein C APC inactive when bound to C4bbinding protein protein Z Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI Protein Zrelated protease inhibitor ZPI Degrades factors X in presence of protein Z and XI independently plasminogen Converts to plasmin lyses fibrin and other proteins alpha 2antiplasmin Inhibits plasmin tissue plasminogen activator tPA Activates plasminogen urokinase Activates plasminogen plasminogen activator inhibitor1 PAI1 Inactivates tPA urokinase endothelial PAI Coagulation also known as clotting is the process by which blood changes from a liquid to a gel forming a blood clot It potentially results in hemostasis the cessation of blood loss from a damaged vessel followed by repair The mechanism of coagulation involves activation adhesion and aggregation of platelets as well as deposition and maturation of fibrin Platelet activation When the endothelium is damaged the normally isolated underlying collagen is exposed to circulating platelets See Answer

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