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Describe how the mitotic spindle, cohesin, APC, separase and securin work together with each other, at...

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Biology

Describe how the mitotic spindle, cohesin, APC, separase andsecurin work together with each other, at the appropriate time inthe mitotic phase of the cell cycle, to align the chromosomes alongthe metaphase plate and how they work together to allow/causeseparation of the sister chromatids. Be specific and detailed.

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Cohesin holds the sister chromatids together from S phase to late metaphase Cohesin binds with unreplicated chromosome in late G1 phase while dissociate from chromosome at onset of anaphase in presence of APC Mitotic spindle apparatus consists of centrosome and    See Answer
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