DELIVERY
1. What were some of the difficulties with administeringinhalational insulin?
2. Why can’t orally administered insulin be effectively used totreat diabetes (think about what type of molecule
insulin is)?
RELEASE
3. When glucose levels are low, insulin is NOT releases by thebeta cells in the pancreas. Which channels are
open and close during this time?
4. When glucose enters the beta cells of the pancreas is thatsimple or facilitated diffusion? Explain how glucose
entering beta cells leads to insulin release into thebloodstream?
5. Is insulin made fresh every time you want to secrete it or isit stored and ready for release at all times?
ACTION
6. Why can’t insulin receptors be inside their target cell?
7. Once insulin is in the bloodstream, explain how itfacilitates the entry of glucose into adipose tissues/cells.Why
does glucose enter and not exit the cell?
8. How does insulin increase the entry of glucose into hepatic(liver) cells during the fed state? What is meant by a
signal cascade?
9. In the fasted state, there is low insulin. Why does glucoseleave liver cells instead of entering the cell?
