Deletion and insertion may cause what s called a FRAMESHIFT meaning the reading frame changes changing the amino acid sequence SUBSTITUTION one base is substituted for another Complete the boxes below Classify each as either Deletion Insertion or Substitution AND as either frameshift missense silent or nonsense hint deletion or insertion will always be frameshift Original DNA Sequence mRNA Sequence Amino Acid Sequence If a substitution changes the amino acid it s called a MISSENSE mutation If a substitution does not change the amino acid it s called a SILENT mutation If a substitution changes the amino acid to a stop it s called a NONSENSE mutation Mutated DNA Sequence 1 What s the mRNA sequence What will be the amino acid sequence Will there likely be effects wid TACAC CTTGGCGA C GA CT AUGUGGAA CCC CU GOUGA Meth 71ypto Aspa Arg List Stop libde Mutated DNA Sequence 2 TACGAC C What s the mRNA sequence What will be the amino acid sequence Will there likely be effects TACATCT M CGACT What kind of mutation is this Mutated DNA Sequence 3 TACAC CTTAGCGACGACT What s the mRNA sequence What will be the amino acid sequence Will there likely be effects ACGACT What kind of mutation is this Mutated DNA Sequence 4 TACAC CTTGGCGACTACT What s the mRNA sequence What will be the amino acid sequence What kind of mutation is this What kind of mutation is this Circle the change Circle the change Circle the change Circle the change