David Pribnow studied the base sequences of promoters in bacteria and bacterial viruses. He found...

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David Pribnow studied the base sequences of promoters in bacteria and bacterial viruses. He found two conserved regions in these promoters (the -10 box and the -35 box). These two regions of the promoter .signal the initiation site bind the sigma subunit that is associated with RNA polymerase attach the correct nucleotide triphosphate to the template DNA strand separate the two DNA strands

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