Daryl is a 32?year?old man who presents with a 6?month history of shortness of breath even...

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Biology

Daryl is a 32?year?old man who presents with a 6?month historyof shortness of breath even during activities that require onlyminor exertion. He has noticed increasing limitation in hisexercise capacity and denies wheezing, cough, or phlegm production.He has smoked for 15 years and continues to smoke. Daryl's fatherhas been told he has early compensated cirrhosis but has neverdrank alcohol; his mother is in good health. Daryl’s serum proteinelectrophoretic results are shown below:     Adultreference Values        PatientResults Albumin 3.5?5.0   3.6 ?1 ? Globulins0.1?0.4   0.0 ?2 ? Globulins 0.6?1.0   0.7 ? ?Globulins 0.7?1.1   0.8 ? – Globulins 0.8?1.6  1.0 Total Protein 6.0?8.0   6.1 Patient’s ElectrophoreticPattern                                 18US MLSC 4051: Clinical Chemistry 4 1. What protein fraction(s)is/are abnormal in the patient’s serum? (0.5 pt) 2. An abnormalityin this/these fraction(s) is/are most often associated with changesin what protein? (1 pt) 3.   What is the function of thisprotein? (1 pt) 4.   Could this protein abnormality berelated to both the patient’s symptoms and his father’s cirrhosis?Explain your answer. (1 pt) 5. What other test(s) may be done toconfirm this abnormality? (1 pt) 6.   What charge is onthe plasma proteins when they are dissolved in the typical pH 8.6electrophoretic buffer? Explain (1 pt)    7.  Are there conditions that will cause an increase in this protein inthe serum? If so, state at least one such condition and list atleast three other specific proteins that would be abnormal inaddition to this protein. (2.5 pts) 8.   Calculate theTotal Globulin levels and the A/G ratio for this patient (1 pt)

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1 Alpha1Globulins normal range for adults is 0104 Darly is 32 year old and hence his serum concentration of Alpha1Globulin should fall within this range But his serum concentration for Alpha1Globulin is 00 which is abnormal 2 Alpha1Globulin are serum globular proteins These serum    See Answer
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