Cyst formation causes a catastrophic loss of function in polycystic kidney disease.Â Â Genetic research has linked this disease...

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Cyst formation causes a catastrophic loss of function inpolycystic kidney disease.Â Â Genetic research has linkedthis disease to defects in genes that code for primary ciliumproteins.Â Â Describe in general terms how malfunctioningprimary cilia cause the formation of kidney cysts.

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Primary cilia are specialized organelles present on most cell types Almost all of proteins associated with a broad spectrum of human cystic kidney diseases have been localized to the region in or around the cilia Abnormal cilia structure andor function have been reported in animal models and human cystic kidneysNovel direct recording of cilia calcium levelchannel activity suggest that cilia form a calciummediated signaling microenvironment separate from the See Answer

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