Cultured liver hepatocytes are convenient for studying both exocytosis and receptor-mediated, clathrin-dependent endocytosis. As part of an...

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Biology

Cultured liver hepatocytes are convenient for studying bothexocytosis and receptor-mediated, clathrin-dependent endocytosis.As part of an advanced laboratory in cell biology, students arerequired to perform mutation studies on cultured liver hepatocytesto generate data that supports the proposed mechanism ofreceptor-mediated, clathrin-dependent endocytosis. Liverhepatocytes are cultured, mutagenized, and screened for defectivereceptor-mediated endocytosis. In order to distinguish uniquemutants from one another, the students must design a series ofexperiments to distinguish between mutants that have the followingmutations:
a). Cellular adaptor proteins are mutated to benon-functional
b). Clathrin is mutated to be non-functional
c). Dynamin is mutated to be non-functional

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Endocytosis It is the process of passing the molecule from outer cellular environment to the intra cellular space across the membrane via receptors present on the membrane In this activated molecule See Answer

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