Consider cargo proteins that are destined for secretion to the extracellular space. Please predict where the...

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Biology

Consider cargo proteins that are destined for secretion to theextracellular space. Please predict where the cargo will end up(ex. in the cytoplasm, a specific organelle, transport vesicles,multiple places, extracellular space) for: (i) & (ii) Eachindividual condition; & (iii) The combination of bothconditions.
C.
(i) v-SNAREs on COPII coated vesicles are mutated to be unableto bind t-SNAREs
(ii) A transmembrane domain is added to the cargo protein.
(iii) Both
D.
(i) Receptors in the Golgi are mutated so they are unable tobind to cargo proteins.
(ii) COPI coat proteins are mutated so they are unable to bindto membranes.
(iii) Both

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4.1 Ratings (574 Votes)

Transport vesicles must ocuur in a highly selective manner so that they recognize the correct target membrane with which to fuse Owing to large diversity of membrane systems a vesicle may likely encounter many potential target membranes before it finds the correct one SNARE proteins seem to have a central role both in providing specificity and in catalyzing the fusion of vesicles with the target membrane There are at least 20 different SNAREs in an animal cell and they exist as complementary sets vesicle membrane SNAREs called vSNAREs and target membrane See Answer

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