Congenital defects in glycogen metabolism can have serious negative effects on human health. Below are several...

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Biology

Congenital defects in glycogen metabolism can have seriousnegative effects on human health. Below are several examples takenfrom box 15.4 in the text. For each example, statehow glucose glycogen metabolism is likelyaltered from an inherited mutation to the stated enzyme (assumethese mutations cause the enzymes to losetheir normal function).
The â€œType 0â€ glycogen storage disease (liver) is caused byglycogen synthase (GYS). Symptoms includelow blood glucose, high ketone bodies, early death.
The â€œType Ia (Von Gierke)â€ glycogen storage disease (liver) iscaused by Glucose 6-phosphatase. Symptomsinclude enlarged liver and kidney failure.
The â€œType VII (Tarui)â€ glycogen storage disease (muscle) iscaused by PFK-1. Symptoms include muscleexercise cramps.
Please answer with explanation. Thank you!

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Type O Liver glycogen storage disease This is caused by the deficiency of glycogen synthase in the liver This leads to accumulation glucose in the blood hyperglycemia Glycogen structure will be normal but present in very little quantity High See Answer

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