Complement pathways _ Explain how classical pathway, Alternative pathway, lectin pathway and terminal pathway are activated to...

60.1K

Verified Solution

Question

Biology

Complement pathways _
Explain how classical pathway, Alternative pathway, lectin pathwayand terminal pathway are activated to destroy bacterial cells?

Answer & Explanation Solved by verified expert

3.6 Ratings (512 Votes)

Most of the proteins and glycoproteins that constitute the complement system are synthesized by hepatocytes But significant amounts are also produced by tissue macrophages blood monocytes and epithelial cells of the genitourinary system and gastrointestinal tract The three pathways of activation all generate homologous variants of the protease C3convertase The classical complement pathway typically requires antigenantibody complexes for activation specific immune response whereas the alternative pathway can be activated by spontaneous complement component 3 C3 hydrolysis foreign material pathogens or damaged cells The mannosebinding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies nonspecific immune response In all three pathways C3convertase cleaves and activates component C3 creating C3a and See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member