Clinical application
Claire Diego is an 11 year old girl livingin Los Angeles. She complains of having to urinate more frequentlywith a large urine volume. She also is very thirsty. She has noprevious illnesses, except that 6 weeks ago she developed a sorethroat. It persisted for 2.5 weeks until she was seen by herpediatrician. At that time it cleared over the next 2 weeks withantibiotics. She is current on her vaccinations. She has had notravel out of the State of California in her life. The family hasno pets or contact with wildlife. Her physical test isunremarkable.
Her blood pressure is 120/77. 
Other labvalues:
Blood sugar = 99 
ADH level = normal
Aldosterone level =normal Urinalysis: albumin = 5+
RBC’s = 40-50/HPF Urine culture =negative 
 If I said this was a renal corpuscle problem, what linkcan you see to the sore throat in her history?

Hint: how couldantigen/antibody complexes and complement, then inflammation, fromthe immune system be involved in the etiology of the abnormality?Look again at filtration pressures in the renal corpuscle. Whichone of the pressures would now be abnormal in this patient?_____________. Assign that pressure 14 mmHg. Now draw a picture ofthe forces effecting filtrate flow through this patient’s renalcorpuscle and show why she is she urinating more. Show her NFP.
