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Cells that accumulate misfolded proteins initiate a stress response that includes reducing protein translation by inhibiting the...

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Biology

Cells that accumulate misfolded proteins initiate a stressresponse that includes reducing protein translation by inhibitingthe initiation stage of translation. First explainthe three stages of initiation of protein translation in eukaryoticcells. Next explain the mechanism by whichtranslation is inhibited as part of the stress response.

The three stages are 43S preinitiation complex, 48S initiationcomplex, and 80S initiation complex but I don't know how to explainthem and what happens during each stage.

Answer & Explanation Solved by verified expert
4.1 Ratings (726 Votes)
in eukaryotic initiation process 1 Initiation factors eIFs binds to the 40S ribosomal subunit eIF2GTP binds to tRNA forming ternary complex eIF3 then binds to the ternary complex and also the 40S subunit forming the 43S initiation complex 2 eIF4Fcomplex eIF4G eIF4EeIF4A    See Answer
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