Catalytic antibodies are prepared against a transition state analog of a substrate. Do catalytic antibodies work because...

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Chemistry

Catalytic antibodies are prepared against a transition stateanalog of a substrate.
Do catalytic antibodies work because they maximize kcat orminimize Km? Justify answer.

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Catalytic Antibodies They are also known asabzymesTransitionstate analogs are also ideal for generating catalyticantibodies abzymesAntibodies immunoglobins may be created to recognizetransition states and thus function as catalysts for thereactionThe transitionstate analog acts as an antigen immunogen togenerate the antibodyAn example of this process is the production of an antibody thatcatalyzes the insertion of an iron ion into the porphyrin planewhich must be bent in order to allow the iron to enterNormally this step is catalyzed by ferrochelatase the finalenzyme in the production of heme Nmethylprotoporphyrin was foundto resemble the transition state because Nalkylation bends theporphyrin much like the ferrochelatase enzymeTherefore an antibody catalyst was produced by using anNalkylporphyrin as the immunogenic The produced antibody is ableto distort the porphyrin in order to facilitate the entry offerrous ironUsing a similar technique antibodies that catalyze ester andamide hydrolysis transesterification and photo induced cleavageamong other reactions have been developedTransitionstate analogPing Pong MechanismFor this mechanism an enzyme can be in two states One of thestates is labeled E and the other state that is also known as See Answer

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