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Case study 8-year old girl with recurrent infections caused by Streptococcus pyogenes and Hemophilus influenza was admitted...

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Medical Sciences

Case study

8-year old girl with recurrent infections caused byStreptococcus pyogenes and Hemophilus influenza was admitted to thehospital following a 5-day sinus infection. Her mother noted thatshe had developed a productive cough and high fever. Her whiteblood cell count was 3200/ul (normal count 5000-9000/ul). 25%percent of her white cells were neutrophils (very low), 40% werelymphocytes (normal), and 29% were monocytes (elevated, normal 2 to8%). A serum test revealed that her IgG level was 35 mg/dl (normal600-1500 mg/dl), IgA was undetectable (normal 150-225 mg/dl) andher IgM level was 210 mg/dl (normal 75-150 mg/dl). A flowcytometric analysis of her peripheral blood cells revealed that allof her B cells were IgM+, IgD+.

  1. Provide a possible diagnostic for the patient.

Answer & Explanation Solved by verified expert
4.1 Ratings (761 Votes)
Possible diagnosis for the condition described in the above mentioned question can be a Hyper IgM syndrome This possible diagnosis is based on the major fact that flow cytometric analysis showed that her her B cells were IgM IgD Along with this observation there was a pyogenic infection There was elevated level of IgM and decreased level of other antibodies up and down levels of other cells    See Answer
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