Can anyone explain in laymen's term? Also, point out keyinformation to put in my introduction/background information slidein bullet points
The gut microbiome consists of a multi-kingdom microbialcommunity. Whilst the role of bacteria as causal contributorsgoverning host physiological development is well established, therole of fungi remains to be determined. Here, we use germ-free micecolonized with defined species of bacteria, fungi, or both todifferentiate the causal role of fungi on microbiome assembly,immune development, susceptibility to colitis, and airwayinflammation. Fungal colonization promotes major shifts inbacterial microbiome ecology, and has an independent effect oninnate and adaptive immune development in young mice. Whileexclusive fungal colonization is insufficient to elicit overtdextran sulfate sodium-induced colitis, bacterial and fungalco-colonization increase colonic inflammation. Ovalbumininducedairway inflammation reveals that bacterial, but not fungalcolonization is necessary to decrease airway inflammation, yetfungi selectively promotes macrophage infiltration in the airway.Together, our findings demonstrate a causal role for fungi inmicrobial ecology and host immune functionality, and thereforeprompt the inclusion of fungi in therapeutic approaches aimed atmodulating early life microbiomes