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Biology of Stem Cells: You injected 1000 Ovarian cancer stem cells into a SCID mouse and a...

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Biology

Biology of Stem Cells:

You injected 1000 Ovarian cancer stem cells into a SCIDmouse and a tumor forms. How do you determine tumorigenic potentialof the cancer stem cells

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The tumorigenic potential of any cells is its ability to form tumors in immunocompromised host Tumorigenic potential of cancer stem cells can be studied by xenotransplantation of subpopulations of cancer cells into flanks of highly immunosuppressive animals such as NODSCID mice Cancer stem cells have the potential to form all kinds of cells cells that are tumorigenic and cells that are not Cancer stem cells phenotypes of selfrenewal and pluripotency are acquired by the activation of oncogenic genes or the inactivation of tumor suppressor    See Answer
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