Biochemistry. What is the key substrate that nitrogen goes onto to enter the Urea Cycle?

70.2K

Verified Solution

Question

Chemistry

Biochemistry.
What is the key substrate that nitrogen goes onto to enter theUrea Cycle?

Answer & Explanation Solved by verified expert

3.6 Ratings (590 Votes)

Alanine and glutamine are the major transporters of nitrogen inthe blood Alanine is produced in a single biochemical step by thetransamination of pyruvate Glutamine is produced from glutamate bythe addition of an amide to the glutamate carboxyl group by anATPdependent reaction catalyzed by glutamine synthetaseNH4 and aspartate the forms in whichnitrogen enters the urea cycle are produced from amino acids inthe liver by a series of transamination and deamination reactionsGlutamate dehydrogenase is a key enzyme in the process because itgenerates the free NH4 previouslytransferred to ketoglutarate from many amino acids bytransaminases As dietary protein increases a proteinrich dietthe concentration of the enzymes of the urea cycle increasesuggesting a regulated response to meet the increased need fornitrogen See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member