Attachment of myelin to the surface of some neurons occurs via the interactions of transmembrane adhesion...

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Biology

Attachment of myelin to the surface of some neurons occurs viathe interactions of transmembrane adhesion molecules expressed onthe myelin membrane with receptors on the target axons. Severalhuman peripheral neuropathies are associated with mutations ingenes encoding theses myelin-associated proteins that disruptmyelin-axon attachment, (1) Explain the symptoms this lossof peripheral myelination might be expected cause and why, giventhe function of myelin in the nervous system. (2) Propose ahypothesis to explain why only peripheral and not central nervoussystem symptoms are observed in these diseases.

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Ans 1 A range of symptoms may present Parasthesia pins and needle sensations are experienced by the patients they may describe it as an ant walking on their skin Numbness If myelin loss increases they can have decreased sensations This is classic in old diabetic See Answer

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