Aspartate transcarbamoylase (ATCase) catalyzes the first step in the biosynthesis of a nucleotide. The end product...
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Aspartate transcarbamoylase (ATCase) catalyzes the first step inthe biosynthesis of a nucleotide. The end product of the pathway,cytidine 5’-triphosphate (CTP), in turn inhibits ATCase activity.This effect can be overcome by the addition of ATP.
a) Sketch the enzyme activity curve of ATCase alone, ATCase +CTP, & ATCase + ATP. Explain your rationale.
b) The regulation of ATCase activity by CTP exemplifies what TWOtypes of regulation?
Aspartate transcarbamoylase (ATCase) catalyzes the first step inthe biosynthesis of a nucleotide. The end product of the pathway,cytidine 5’-triphosphate (CTP), in turn inhibits ATCase activity.This effect can be overcome by the addition of ATP.
a) Sketch the enzyme activity curve of ATCase alone, ATCase +CTP, & ATCase + ATP. Explain your rationale.
b) The regulation of ATCase activity by CTP exemplifies what TWOtypes of regulation?
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