Angiotensin-converting enzyme (ACE) inhibitor drug enalaprilat is used to treat hypertension and has poor oral bioavailability...

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Biology

Angiotensin-converting enzyme (ACE) inhibitor drug enalaprilatis used to treat hypertension and has poor oral bioavailability aswell as a short half-life. What functional groups and properties ofthe drug may be responsible for these drawbacks and what can bedone to modify the structure to improve both oral bioavailabilityand half-life?

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Description Enalapril is a dicarbocylcontaining peptide and angiotensinconverting enzyme ACE inhibitor with antihypertensive activity As a prodrug enalapril is converted by deesterification into its active form enalaprilat Enalaprilat competitively binds to and inhibits ACE thereby blocking the conversion of angiotensin I to angiotensin II This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation Enalapril also decreases angiotensin IIinduced aldosterone secretion by the See Answer

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