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Angiogenesis is an essential property of many solid tumors, and the target of several anticancer drugs....

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Biology

Angiogenesis is an essential property of many solid tumors, andthe target of several anticancer drugs. One clinically importantangiogenic pathway involves vascular endothelial growth factor(VEGF) and its cognate receptors.

a) What is VEGF and how is it important in tumor growth andsurvival?

b). What agents target the VEGF pathway and what are theirmechanisms of action?

c.) What kinds of tumors are effectively treated with agentsthat target the VEGF pathway?

d) What are the important toxicities of the agents that targetthe VEGF pathway?

Answer & Explanation Solved by verified expert
4.3 Ratings (837 Votes)
a vascular endothelial growth factor is a produced by many types of cells such as macrophages platelets and tumor cells these are involved in many physiological functions such as haematopoeisis    See Answer
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