An experimental mouse model of Leishmania infection was used by Nathan and Miller to investigate the relative...

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Biology

An experimental mouse model of Leishmania infectionwas used by
Nathan and Miller to investigate the relative contribution ofreactive
oxygen intermediates (ROIs) and reactive nitrogenintermediates
(RNIs) in the control of leishmaniasis.
i) How did the authors establish that RNIs but not ROIs areessential and
sufficient to limit an infection?
ii) How are these toxic intermediates generated by redoxreactions
and what mechanisms protect the parasite against theirtoxicity?

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4.4 Ratings (695 Votes)

i Nathan and Miller experiments on Leishmania donovani was done in experimental mouse models in order to determine the relative contributions of respiratory burstderived reactive oxygen intermediates ROI versus reactive nitrogen intermediates RNI to macrophagemediated intracellular host defense They used mice genetically deficient in these mechanisms and were challenged with Leishmania donovani a protozoan that selectively parasitizes visceral tissue macrophages The experimental mice were either lacking mechanism for See Answer

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