An experimental mouse model of Leishmania infectionwas used by
Nathan and Miller to investigate the relative contribution ofreactive
oxygen intermediates (ROIs) and reactive nitrogenintermediates
(RNIs) in the control of leishmaniasis.
i) How did the authors establish that RNIs but not ROIs areessential and
sufficient to limit an infection?
ii) How are these toxic intermediates generated by redoxreactions
and what mechanisms protect the parasite against theirtoxicity?
