After ovulation, the granulosa cells from the ovulated follicledifferentiate into luteal cells. Steroid production by granulosacells in a developing follicle is different from those forming thecorpus luteum because:
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| secretion of hormones by the luteal cells has negative feedbackeffects on the hypothalamus and pituitary whereas secretion by thegranulosa cells has only positive feedback effects. |
| steroid hormone secretion by the granulosa cells mainly promotesthe formation of secretory glands in the endometrium, whereasluteal cell secretions mainly promote endometrialproliferation. |
| the luteal cells predominantly secrete estradiol, whereas thegranulosa cells mainly secrete estriol. |
| the granulosa cells have receptors for hCG (human chorionicgonadotropin), whereas luteal cells have no hCG receptors. |
| the granulosa cells have only FSH receptors whereas the lutealcells contain receptors for both FSH and LH and are therefore ableto synthesize more progesterone. |
