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Advair, a combine bronchodilator and inhaled steroid is relatively slow working. Usually a patient has to...

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Basic Math

Advair, a combine bronchodilator and inhaled steroid isrelatively slow working. Usually a patient has to wait at least anhour before the full effect of this medicine kicks in. We wereinterested whether the patients could be reclassified (from severeto moderate COPD) within one-hour based on their Advairintervention. Measurements were made before the Advair wasadministered and then exactly one-hour after the treatment. Hereare the data.

Advair Intervention - Test #2a

Before Treatment

After Treatment

Severe

Moderate

Total

Severe

253

600

853

Moderate

513

188

701

Total

766

788

1554

So over 1,500 patients were studied. Of the 1,554, 853 (or 55%)were classified as being severe COPD patients before the Advairintervention and then after the intervention, this number droppedto 766 (or 50%).

So it appears there was an effect within the one-hour timeperiod. Now we need to show it statistically.

So using the McNemar test, test the claim at 95% confidence thatthere was an Advair intervention effect.

  1. State the Null and Alternative Hypotheses (1)
  2. State the Decision Rule (2)
  3. Determine the McNemar test statistic (3)

State your Decision and Interpretation. (1,1)

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