Acetylcholine is a chemical signaling molecule used to facilitate communication between neighboring neurons Acetylcholinesterase AChE is an enzyme that catalyzes the conver sion of acetylcholine to acetate and choline When the concentration of AChE in an aque ous solution is held constant the rate of the reaction catalyzed by AChE increases with in creasing concentrations of substrate At conditions in which the concentration of acetylcholinesterase is relatively low a small in crease in the substrate concentration results in a large increase in the reaction rate At con ditions in which the concentration of acetylcholinesterase is relatively high however a large increase in the substrate concentration results in only a small increase in the reaction rate Which of the following best explains the difference in the change in the rate of the cat alyzed reaction between the two conditions A B C The enzyme AChE becomes denatured as the acetylcholine concentration of acetyl choline increases The active site of AChE can only bind a single substrate at a time ACHE begins converting the product into the substrate as the acetylcholine concentra tion increases D The substrate binding specificity of AChE decreases as the concentration of acetyl choline increases