A. What is the ? (alpha)- helical dipole and what is the molecular origin of that...

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Chemistry

A. What is the ? (alpha)- helical dipole and what is themolecular origin of that dipole?
B. Identify two amino acids that are preferred in ? (beta)-sheets. Why might these amino acids be preferred?
C. Peptide bonds are believed to by hydrated by three watermolecules, with one hydrogen bond donated from the N-H and twohydrogen bonds being accepted by the lone pairs of electrons in thecarbonyl group. Would you expect a significant entropic componentto be associated with the formation of secondary structures likealpha-helicies and beta-sheets. Explain.

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1 Since the alpha helix is the most commonly occurring type of secondary structure in proteins and as there is quite a variation in the frequency of occurrence of the various amino acid residues in alpha helices mutations within alpha helices are of considerable importance Alanine is the most stabilizing residue whereas glycine destabilizes the helix relative to alanine by 0708 kcalmol and proline by 34 kcalmolTherefore a long stretch of alpha helix substituted by alanine gives a more stable protein The alignment See Answer

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